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Make the switch from IR to MOTPOLY XR
- For patients who are already on a single AED and will convert to MOTPOLY XR monotherapy, withdrawal of the concomitant AED should not occur until the therapeutic dosage of MOTPOLY XR is achieved and has been administered for at least 4 days. A gradual withdrawal of the concomitant AED over at least 6 weeks is recommended1
- For patients with severe renal impairment, the maximum recommended dose of MOTPOLY XR is 300 mg1
- MOTPOLY XR is not recommended in patients with severe hepatic impairment1
- MOTPOLY XR may be taken with or without food1
- MOTPOLY XR capsules should be swallowed whole with liquid. Patients should not open, chew, or crush the capsules1
AED=anti-epileptic drug.
MOTPOLY XR provides dosing convenience for new patients
Dosing recommendations for new starts1*
- For patients with mild or moderate hepatic impairment, the maximum recommended dosage is 300 mg. Use in patients with severe hepatic impairment is not recommended1
- For patients with severe renal impairment, the maximum recommended dose of MOTPOLY XR is 300 mg1
- Dose reduction may be necessary in patients with hepatic or renal impairment who are taking strong inhibitors of CYP3A4 and CYP2C91
* When not specified, the dosage is the same for monotherapy for partial‑onset seizures and adjunctive therapy for partial‑onset seizures.
† Monotherapy for partial-onset seizures only.